Are you currently searching for innovative solutions to address your mental health concerns? Ketamine-assisted therapy could be the beacon of hope you’ve been looking for, especially if you have been struggling with treatment-resistant conditions. This revolutionary therapy is transforming lives by providing rapid relief for issues like treatment-resistant depression and PTSD. Our guide aims to demystify the science and real-life experiences behind ketamine-assisted therapy, providing informative insights without being overwhelming.

Key Takeaways

  • Ketamine assisted therapy provides rapid relief by acting as an NMDA receptor antagonist. Ketamine increases levels of glutamate and BDNF, which leads to the formation of new neural connections, proving beneficial for treatment-resistant depression, PTSD, anxiety, and chronic pain.¹
  • Beyond alleviating symptoms, ketamine assisted therapy can help facilitate significant personal growth, emotional resilience, and stronger interpersonal relationships through enhanced neuroplasticity and mindset shifts.
  • Plus by APN provides personalized mental health treatment, including ketamine assisted therapy, backed by a multidisciplinary team offering cutting-edge holistic well-being treatments.

What is Ketamine Assisted Therapy?

Ketamine assisted therapy represents a cutting-edge approach to mental health treatment, combining the administration of ketamine – a substance known for its rapid-acting antidepressant properties – with traditional psychotherapeutic methods. This innovative treatment is particularly effective for conditions that have proven resistant to conventional therapies, such as treatment-resistant depression and PTSD. 

Through its unique mechanism of action, ketamine assisted therapy offers new hope and pathways for healing, addressing the root causes of mental health issues while fostering significant personal growth and improvement in life quality.

How it Works: The Science Behind Ketamine Assisted Therapy

Ketamine assisted therapy is an innovative mental health treatment that harmoniously combines medically-administered ketamine with psychotherapy to address mental health conditions. Developed initially as a dissociative anesthetic, ketamine has shown rapid antidepressant effects. 

Ketamine acts as an N-methyl-D-aspartate (NMDA) receptor antagonist to regulate mood by triggering a surge in glutamate and brain-derived neurotrophic factor (BDNF) to create new neural pathways.¹ This process improves synaptic plasticity and neuroplasticity, effectively rewiring the brain for healthier functioning. 

Ketamine is a promising development in the field of psychedelic-assisted psychotherapy, offering more than symptom treatment by targeting the root causes of mental health issues.

Rapid Relief for Treatment-Resistant Depression

For individuals feeling trapped by treatment-resistant depression, ketamine assisted psychotherapy emerges as a beacon of hope.² Unlike traditional antidepressants, ketamine swiftly alleviates depressive symptoms, sometimes within hours, bypassing the weeks usually needed for conventional treatments. Ketamine’s unique ability to enhance neuroplasticity allows for rapid behavioral and thought pattern changes, offering a brighter, healthier future.

PTSD Management

PTSD can imprison individuals within their traumatic memories. Ketamine assisted therapy offers liberation and hope, providing a new pathway to healing. Studies highlight ketamine’s effectiveness in reducing PTSD symptoms, although its benefits require further exploration for long-term efficacy.³ Ketamine facilitates emotionally safe access to traumatic memories, enabling profound processing, healing, and self-awareness, marking a critical step towards recovery.

Addressing Anxiety Disorders and Chronic Pain

Ketamine therapy can help those suffering from anxiety disorders that often resisting traditional treatments, leaving individuals paralyzed with fear.⁴ Ketamine Assisted Therapy introduces a novel solution to anxiety, targeting the root of anxiety symptoms by modulating the glutamatergic system. This modulation reduces neural circuit hyperexcitability to calm the nervous system and offer new hope for individuals struggling with anxiety. Additionally, ketamine offers relief from chronic pain by altering pain perception, providing a reprieve for those burdened by daily discomfort.⁵

Personal Growth and Self-Discovery

Ketamine assisted therapy goes beyond treating mental health conditions to help individuals progress along a journey of self-discovery and growth. By facilitating shifts in mindset and self-perception, ketamine lays the groundwork for personal transformation.⁶ The therapy’s dissociative effects open the door to mental breakthroughs, fostering self-reflection and discovery.

Enhancing Emotional Resilience and Strengthening Interpersonal Relationships

Building emotional resilience and strengthening relationships can help improve overall well-being. Ketamine therapy strengthens mental resilience and enhances the capacity to navigate life’s challenges. Additionally, it improves emotional well-being, allowing for deeper connections and effective conflict resolution, thereby enriching relationships.

The Plus by APN Approach: Comprehensive Mental Health Treatment

At Plus by APN, we merge cutting-edge healthcare methodologies with advanced interventional psychiatry to offer a holistic solution to mental health care. We work with each client to design a custom-built approach, that empowers individuals with aunique mental wellness path.

At Plus by APN, we meticulously design treatment plans, drawing on an in-depth understanding of each patient’s history to meet their specific needs. 

Backed By A Multidisciplinary Team of Experts

The Plus by APN approach is comprehensive and combines modern healthcare with interventional psychiatry to offer personalized, cutting-edge treatments. Our multidisciplinary team works with you to ensure a holistic path towards mental wellness.

Cutting-Edge Treatments We Offer

At Plus by APN, we provide a suite of state-of-the-art treatments, including:

  • Deep Transcranial Magnetic Stimulation (dTMS)
  • Ketamine Treatment
  • Stellate Ganglion Blocks (SGB)
  • Hyperbaric Oxygen Therapy (HBOT)

These modalities, supported by the latest in scientific research, underscore our commitment to delivering comprehensive care in mental health treatment. Book a consultation today to begin your journey to wellness.

Frequently Asked Questions

What is Clinical Depression?

Clinical depression, or major depressive disorder (MDD), is a mental health condition characterized by a prolonged period of low mood and a lack of interest in activities. This condition deeply affects one’s sleep patterns, appetite, and thought processes, and can significantly impair both emotional and physical well-being.

What is a Mental Disorder?

Mental disorders, also referred to as mental health disorders, cover a broad spectrum of conditions that influence mood, thinking, and behavior. These disorders, including depression, anxiety disorders, schizophrenia, and many others, can disrupt daily life and impair an individual’s ability to interact with others effectively.

What is an Anxiety Disorder?

An anxiety disorder is marked by excessive and persistent worry that adversely affects day-to-day functioning. This disorder presents with physical symptoms such as restlessness, muscle tension, and difficulty sleeping, and can significantly impact an individual’s overall quality of life and well-being.

What is Post-Traumatic Stress Disorder (PTSD)?

Post-traumatic stress disorder (PTSD) develops after exposure to a traumatizing event or ordeal that caused or threatened grave harm, either physically or emotionally PTSD is a serious condition that manifests through lasting, distressing memories of the trauma, along with emotional numbness and other life-impacting symptoms. Recognizing and addressing PTSD symptoms and the root cause of PTSD are crucial for the affected individual’s recovery and well-being.

Final Thoughts

Ketamine assisted herapy represents a groundbreaking shift in mental health care, emphasizing the treatment of underlying causes, promoting mental flexibility, and encouraging profound personal growth. Plus by APN embodies a holistic approach to mental wellness, leveraging a blend of expertise and innovative treatments. This therapy promises relief and a journey toward self-discovery and lasting change, shining a light on the future of mental health care.


  • Orser, B A et al. “Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors.” Anesthesiology vol. 86,4 (1997): 903-17. doi:10.1097/00000542-199704000-00021
  • Serafini, Gianluca et al. “The role of ketamine in treatment-resistant depression: a systematic review.” Current neuropharmacology vol. 12,5 (2014): 444-61. doi:10.2174/1570159X12666140619204251
  • Du, Rui et al. “The Multivariate Effect of Ketamine on PTSD: Systematic Review and Meta-Analysis.” Frontiers in psychiatry vol. 13 813103. 9 Mar. 2022, doi:10.3389/fpsyt.2022.813103
  • Hietamies, Tuuli M et al. “The effects of ketamine on symptoms of depression and anxiety in real-world care settings: A retrospective controlled analysis.” Journal of affective disorders vol. 335 (2023): 484-492. doi:10.1016/j.jad.2023.04.141
  • Orhurhu VJ, Roberts JS, Ly N, et al. Ketamine in Acute and Chronic Pain Management. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from:

Drozdz, Sandra J et al. “Ketamine Assisted Psychotherapy: A Systematic Narrative Review of the Literature.” Journal of pain research vol. 15 1691-1706. 15 Jun. 2022, doi:10.2147/JPR.S360733